New study indicates that there is a genetic defect that reduces the number of T cell receptors in the immune system which leads to the immune system turning on and not being able to turn off.  This in turn leads to a feedback loop of inflammation, Krebs cycle malfunction, mito dysfunction and immune system activation.  When the mitochondria crap out, everything craps out and it turns into a systemic illness.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872418/
If this study is verified, then this is most likely THE cause of CFS/ME.  It is the root of all the other problems.  I'm just wondering if CRISPER could be used to repair the genetic damage and fix this illness once and for all.  A girl can dream.....