Showing posts with label biology. Show all posts
Showing posts with label biology. Show all posts

Friday, January 22, 2016

The Detoxification of Women's Bodies

Detoxing is all the rage.  However, its definition is a tad fuzzy and there are tons of  unscrupulous folk willing to scam you out of your money over it.  My first clue regarding the definition was when I told my CFS doc that I was having detox problems with my glutathione IVs.  He asked me what exactly I meant by that and I had to go into a lengthy explanation of what was happening to my body.  This should have cued me into the ramifications of detoxification language but I was messed up enough at the time to only get slightly aggravated with my doc for being so dense.  Lately, however, I've noticed something that I find disturbing.  I don't know if this is new since I'm relatively new in the chronic illness sphere.  It might have been around for years or decades.  Also, this is fairly difficult for me to describe since the evidence for my disquietude is subtle.  So let me start with language.

Language is a powerful thing and the way we use language can give us insight into how the mind is functioning both in a neurophysical sense and a psychological sense.  An example of a neurophysical glitch would be word loss/substitution.  Calling your pets your furbabies might be an indication that you are substituting your pets for actual children on a psychological level.  What is disturbing me is the way women tend to discuss detoxification.  

Our bodies do indeed have many real detoxification pathways that can break.  The methylation (MTHFR) pathway broke in me and I got very sick as a result.  I needed glutathione IVs, activated charcoal, bentonite clay and B12 to get thing working again. There are also liver pathways (CY9 SNPs), the lymphatic system and probably a few others I don't know anything about yet.  Our bodies can also break in another way; for example leaky gut, where toxins that normally wouldn't be allowed in, sneak in through gaps between the cells lining the gut.  So there are ways that we can break that allow stuff in (leaky gut or leaky brain barrier or even broken skin) and ways that we can break where we can't adequately eliminate toxins from our system (MTHFR, CY9 defects or even not being able to poop regularly).  These are biochemical and physical glitches in our system.  They can be tested for and for the most part fixed or worked around given the right supplements and/or meds and/or diet.
We can also reduce the toxic burden on our bodies by eating clean, removing toxins from our environment, using air and water filters, etc.  The idea is that the fewer toxins we are exposed to then the less the body has to work to eliminate because the toxins were never ingested/absorbed in the first place.

Now here is where it starts to get weird.  When I first started the B12 and folate protocol for MTHFR I started bleeding heavily for weeks on end.  It took me a while to figure out that it coincided with the vitamins.  When I asked about it I was told by several women "Oh that is just the body detoxing.  Don't worry about it.".  I accepted this explanation and tried to continue with the protocol.  This lead to anemia from the excessive blood loss.  I even ended up in the ER at one point with a UT probe up my hoohoo (very uncomfortable BTW) with no evidence that there was anything causing the bleeding.  Taking high doses of fish oil leads to the same thing for me.  I was put on high doses of progesterone to halt the bleeding and there was even talk about cauterization of my uterus to prevent it from happening again.  Not a route I wanted to go so I stopped taking fish oil, B12 and folate which stopped the bleeding.  But this idea that my uterus was detoxing started niggling at me.

Other women were experiencing the same side effects as me but I have yet to find a scientific explanation for it.  The male docs I talked to had never heard of it and the women assumed that their bodies were toxic/dirty and trying to self correct through a detox process that doesn't exist.  While you do indeed detox via breath, sweat, pee and poop, I've never EVER heard of detoxing through the uterus.  I certainly didn't bleed heavily while I was on glutathione IVs even though the detoxification was so drastic that I had to take charcoal or clay after a treatment to reduce the herxing.  

Now you have to realize that women have been told for centuries that bleeding is dirty.  Our lady parts are dirty.  They must be cleaned, deodorized and sanitized.  Companies make a fortune convincing us to use tampons, pads, deodorants, soaps, shampoos and, more recently, shaving all our hair off.  So the idea that our uterus must be detoxed isn't a stretch.  In fact I just found this article:

Doctors Warn Against Using Herbal Tampons To "Detox the Womb"

which describes little herbal sachets that go into your vagina to cleanse it.

I've noticed in some of the patient pages that women often go for the detoxing first.  They assume that their bodies are contaminated and dirty and need cleaning.  This is even before they get tested for ANYTHING, genetics, vitamin deficiency, glutathione levels, ANYTHING.  I never seen the guys do this.  True these spaces are mostly populated by female patients so my sampling is severely skewed, BUT given the history of "dirty women's bodies that must be cleansed" it isn't much of a stretch that women are now assuming that they must be detoxed with little to no evidence.  You see it in the huge sales of juice fasts, sugar detox diets, Whole30 resets, etc.   It is just assumed that our bodies are contaminated and must be fixed.

I'm still trying to work through these ideas.  There is some line that needs to be drawn between actual physical problems when the body breaks and this idea that we are necessarily dirty and must be cleansed at all costs.  If our bodies work properly, then they detox themselves just fine.  There are rumors about yoga gurus that can drink poison without any ill effects because they have trained their body to detox itself very efficiently, but I digress...  I guess I'm trying to get away from the idea that women are necessarily dirty, that our natural state is unclean or that because we are sick we must be toxic.  I keep seeing in the patient forums the language women use to describe detoxing in relation to their bodies and it often reminds me of the "women are dirty and must be cleansed" line of thought.  While we might break, we are most often fixable but we are not necessarily dirty.  It is very hard to find examples of the language I'm referring to since it is very subtle.  For me, it has been a cumulative thing rather than one big glaring example.   Never the less it still worries me.  We need to hold ourselves in higher esteem.  Get tested first.  Don't assume that you are dirty/contaminated.  Find out what is broken and fix that rather than going on random and possibly dangerous detoxification protocols that might not have any science behind them at all.  Our bodies are miraculous objects that can handle toxins when working properly.  And, no, you do NOT detox through uterine bleeding.  That is just plain nonsense akin to bloodletting with leeches.  If you are bleeding, stop the protocol before you get anemia.

However, I still have no idea why B12, folate and fish oil cause heavy bleeding.   In that regard, the medical mystery continues.   In the meantime, I do want to be more mindful about how I discuss and think about detoxification.  Language matters and my uterus does NOT need detoxifying, thank you very much.


Wednesday, March 26, 2014

Today's Headlines

Some very interesting snippets in the news today.

Potential treatment option in the works for CFS.  A company has combined a specialized supplement for mitochondria with low dose ritalin that seems to work for CFS symptom improvement.  It is currently going into a double blind placebo study (the gold standard).  BTW, it is being developed by a man that suffers from CFS himself.  Woot!!
http://www.marinij.com/marinnews/ci_25395316/mill-valley-company-develops-treatment-mysterious-chronic-fatigue

The next potential treatment is an antiviral drug being tested on fibro patients.  It is further off on the horizon though.  It has completed phase 1 and phase 2 trials (animals and small batch of humans) and now is raising money for phase 3 (double blind placebo on a large cohort).  It will be a few years before patients will be recruited, whereas the ritalin trial is already in the recruitment phase.
http://www.cortjohnson.org/blog/2014/03/24/pridgen-reports-fibromyalgia-antiviral-trial-results-positive/#comment-303641

And in the way way far off future.  It appears that someone has figured out how to flip genes on and off.  Now this sounds minor but this can have a MAJOR impact on the future of medicine.  If I could go in and fix my MTHFR genes, then I would probably get way way better than I am.  Potential fully cured.  Right now the only discussion is around cancer cures but anyone with a genetic problem should be jumping for joy with this breakthrough.
http://www.the-scientist.com/?articles.view/articleNo/39545/title/DNA-Bends-Control-Gene-Activation/

Then we have this: a bacterial Frankenstein....
http://www.sciencedaily.com/releases/2014/03/140323152144.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news%2Ftop_science+%28ScienceDaily%3A+Top+Science+News%29&utm_content=FaceBook
This just scares the crap out of me.  Then again it might be harnessed for good.  One hopes anyway...


Friday, February 7, 2014

The Gut and the Immune System

I know I've been absent for a while.  Shortly after kitty passed away I got to spend some quality time in the local hospital (I'll talk about that in another post) and then adopted two new kittens which have been running me ragged.  On top of all of this I'm in the middle of my normal winter crash and have little to no energy.  So here is a cool vid that won an award.  It explains how the gut and the immune system interact.  I'm going to have to watch it several times over since it isn't sinking in right now but I love the graphics and I recognize a lot of the tags from various CFS papers/articles.


Saturday, October 19, 2013

Broken Mitochondria

After doing lots of reading (mostly during the first year I was sick when I could still read), I decided that my mitochondria were probably on the fritz.  This leads to some interesting problems including but not limited to glutathione depletion; not being able to detox; not being able to produce energy; not metabolizing food properly; and apparently the way I store and use fat.

So here is the latest roundup of articles on the methylation cycle and otherwise misbehaving mitochondria.






And some bonus material on the cause of Fibromyalgia:

Wednesday, June 12, 2013

Gut Cam

This reminds me of that old science fiction movie, Fantastic Voyage.  I saw it as a kid and thought it was wonderful.  I was riveted by it.  Anyway, here is a real camera that has been swallowed by a gastroenterologist to give you a second hand tour of his guts.



Ooohh I found the trailer to Fantastic Voyage


Tuesday, May 21, 2013

Tech Vid About Gut Lining

This is a somewhat technical video about how the gut lining works.  While they mention IBS specifically, the way the gut works and doesn't work is the same when the gut becomes damaged.  This could be some of the problem in CFS.  The good news is that it can be cured via diet.

http://bcove.me/4wul3t4o

Friday, June 1, 2012

Virus Hijacks Mitochodria

This is a short interpretation of a paper I (sort of) read yesterday (I skipped around a lot and read the short version of it on another web site).
"To spread, nervous system viruses sabotage cell, hijack transportation" by Morgan Kelly, 
http://medicalxpress.com/news/2012-05-nervous-viruses-sabotage-cell-hijack.html
So here is the crux of the study:
  • Virus floods the mitochodria with calcium
  • Mitochodria stop moving and release one of its transport proteins to virus
  • Virus can now move using the stolen transport protein to invade nervous system
  • Mitochodria are frozen in place since they can no longer move due to missing transport protein
WARNING:  This study was only done in rats with only the herpes simplex virus (HSV-1) so it is too early to tell if this happens with other viruses.  However, this would explain a lot of the mitochodria dysfunction seen in CFS.  The author even suggests this might be the mechanism occurring in polio and West Nile.

Some cool pics/vids to help explain this:

http://s.ph-cdn.com/newman/gfx/news/hires/2012/tospreadnerv.jpg

Harvard has two amazing vids that are animations of what goes on inside cells.  I wish they had narration so that I knew what was what and what is going on.  However, start with "The Inner Life of the Cell" which show the assembly of the microtubule and the Kinesin-1 protein hauling a cell along the tubule.  Then, for giggles, watch "The Mitochodria" which shows a mitochodria working properly.  They actually show the lipid rafts on the mito wall that allow other cells to pass through the wall.
http://multimedia.mcb.harvard.edu/
To see both vids you might have to click on the Mito one first, then exit, which dumps you to the page that has both vids on it.

Alternatively you can watch this vid of the animator explaining his work at a TED conference.  It has the clip of the Kinesin walking along the microtubule towards the end of the talk.



When you are done with those vids, go to the paper itself and watch the embedded vid that shows normal mito running around and then mito after viral infection.  http://medicalxpress.com/news/2012-05-nervous-viruses-sabotage-cell-hijack.html

Thursday, October 20, 2011

Bacterium, Viruses and Your Guts

I've been following with interest the studies coming out regarding gut health and illness.  This seems to back up my theory that I can at least partially heal through diet.  Here are a couple of articles that I found interesting today:

BBC writer Ed Yong
How do our bacteria help us?
http://www.bbc.co.uk/news/magazine-15356016?utm_source=twitterfeed&utm_medium=twitter

Science Daily

Research Could Lead to New Treatments for Inflammatory Bowel Disease (IBD) and Viral Infections



Curiouser and curiouser.

Tuesday, January 18, 2011

Eye See You Mr. ME

Being an optics geek and a geek in general I've always been fascinated by eyeballs and how they work.  My early fascination with them probably started when I had eye surgery when I was six to correct lazy eye and I've been learning about them ever since.

Eyeballs are pretty primitive actually.  You can think of them like a water balloon.  Kind of roundish and squishy.  They are literally a sack filled with fluid.  Then if you cut a hole in the balloon exactly opposite the knot and glue a lens in place, you have a pretty good replica.  Now add an imaging plane (photographic film) inside the balloon centered over the knot and you have an eyeball.  I think of the knot as the nerve cluster that heads off to the brain to transport the visual data from the imaging plane to the visual cortex in the brain.

The main problem with eyeballs is getting the balloon to focus the image coming from the lens onto the film so that the picture isn't fuzzy.  This is done with muscles.  So now add a pair of hands squishing and squeezing the balloon and you have an eyeball that can focus an image onto the film that can now be transmitted to the brain and the picture will be in focus.

What does this have to do with Mr. ME?  Muscles.  You are using muscles all the time you are using your eyes.  Muscles not only move your eyes around in their sockets but also squeeze them to maintain and change focus so that you can see objects up close or at distance.  Mr. ME doesn't let us use our muscles much before they become fatigued and this includes our eyes. 

Now reading and computer work in particular are difficult things for our eyes to do for any length of time even if we are healthy.  Eye fatigue from computer use is very common.  Did you know that you blink less when you stare at a computer screen?  This causes our eyeballs to dry out even in healthy people and increases eye fatigue. 

Our eyes aren't designed to be static.  When outdoors we are always looking around and constantly changing our focus.  Reading a computer screen is like standing still holding a 5lb pail out straight with our arm.  It isn't heavy at first but just wait until your arm gets tired.  It soon feels like it weights 5 tons instead of 5lbs.  This is what we are doing to our eyes using a computer.  We are forcing our eyeballs to stay at exactly the same focal distance for hours.  Now add CFS to the mix and it is no wonder that we have trouble reading and using a computer.

What to do?  Here are some tips and tricks from cubical world to help with reading:

  • Use indirect light.  Never ever ever have a light pointed directly at or over a computer screen.
  • On the other hand use really good lighting when reading a book or get the audio version.  My library has books that can be downloaded to my computer or I can get little dedicated MP3 player books from the library itself.
  • Use incandescent light in areas that you are trying to read (books or computer).  Eliminate florescent lighting in the area including CFLs.
  • For computer work use low room lighting directed away from your screen which is preferably incandescent.
  • Look away about every 15 minutes, defocus your eyes, look out the window to get your eyes to focus long distance.  The further away the better.  This is done naturally when flipping a page in a book.  Use a software timer to interrupt you if you get absorbed in material like I do.
  • Site your desk or chair near a window so you can look up and out frequently
  • Look away and blink rapidly and then close your eyes to remoisturize them
  • Lower the brightness level of your screen
  • Lower the contrast levels of your screen
  • Move the computer monitor as far away from you as possible.
  • Use writing software that allows you to change the background color.  White is very fatiguing.  Just look at the Kindle; they actually use a soft gray screen so that it is easier on the eyes.  It is also another reason books are easier to read than a computer screen.
  • Use an antiglare shield on the screen
  • You can even adjust the brightness of the TV set so that it is softer.  Again use low room light and sit as far away from the TV screen as you can.
  • Take frequent breaks.  Put down the reading and do a little stretching.  You don't have to necessarily get up.  Just move around a bit.  Wiggle.  Rest the eyes.
  • When I watch commercial TV I close my eyes during commercials to give them a rest.
  • Use the zoom function on the computer to enlarge the screen.  It makes things way easier to read.  I have it permanently set at 150% and often increase it to 200% or 400% if I am having trouble focusing on something in particular.
  • Fiddle with the assistive tech built into the computer software
    • On Windows go into the Control Panel and look for the wheelchair icon.
    • Vista has text to speech, contrast controls, mouse controls that make it easier to point and click and see the cursor, the ability to stop animations and get rid of background pics
  • Use text to speech software
  • Use speech to text software.  I used Dragon Naturally Speaking about six years ago when I was having problems with my hands.  I used the full version which is expensive but it is one of the better products on the market.  I did hate the autofill function which often guessed wrong and I did spend a considerable amount of time fixing what it typed.  You can get a home edition at Costco for about $60.
  • Do some eye palming (see first video)
  • Do some eye yoga (see second video).  I used to do an almost identical practice with my yoga teacher.  This is an excellent video and the exercises can be done lying down.  Bonus!!






Other resources:

http://www.visionworksusa.com/ vision exercises and nutrition by an ophthalmologist
http://www.aoa.org/x4724.xml
http://www.working-well.org/index.html While this about ergonomics for healthy people, FM and CFS folk are even more suseptible the effects of bad posture and repetition.  This site has tons of information and resources.
 http://www.afb.org/section.asp?Documentid=787 state libraries for people with print disabilities i.e. LOTS of digital books

Feel free to add to the list of suggestion or links.

Wednesday, December 22, 2010

Life of a Cell

CFS is believed to be related to dysfunction in the mitochondria of our cells.  While the idea is somewhat controversial, it does make some sense since the mitochondria are the energy factories for our cells.  I wish I could embed these videos in my blog but you are going to have to scoot over to the Harvard web site to watch.  I recommend the one on mitochondria and the narrated Life of a Cell.  Now I am no biologist and I can't follow half of what they are talking about but the animation is just amazing and I am truly in awe of how our body functions.  Can you believe that all of these little cellular engines are constantly at work in our bodies making us able to eat, talk and breath?  It is truly amazing!  Don't worry I'm going to keep reading and learning biology.  Someday I will be able to interpret what they are saying in the videos.  Hopefully there will be a cure for CFS before then and I won't be posting that interpretation in this blog.